Search results for "locally advanced cervical cancer"

showing 5 items of 5 documents

Completion Surgery After Concomitant Chemoradiation in Locally Advanced Cervical Cancer: A Comprehensive Analysis of Pattern of Postoperative Complic…

2014

Background: We provided a comprehensive analysis of rate, pattern, and severity of early and late postoperative complications in a very large, single-institution series of locally advanced cervical cancer (LACC) patients administered CT/RT plus radical surgery (RS). Methods: A total of 362 consecutive LACC (FIGO stage IB2-IVA) patients were submitted to RS after CT/RT at the Gynecologic Oncology Unit of the Catholic University (Rome/Campobasso). At 4 weeks after CT/RT, patients were evaluated for objective response and triaged to radical hysterectomy and pelvic ± aortic lymphadenectomy. Surgical morbidity was classified according to the Chassagne's grading system. Results: Most cases underw…

Malecervical cancermedicine.medical_treatmentUterine Cervical NeoplasmsPostoperative ComplicationsAntineoplastic Combined Chemotherapy Protocols80 and overlocally advanced cervical cancerAdjuvantSettore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIAAged 80 and overCervical cancerMedicine (all)Middle AgedPrognosisCombined Modality TherapyAdult; Aged; Aged; 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Squamous Cell; Chemotherapy; Adjuvant; Cisplatin; Combined Modality Therapy; Female; Fluorouracil; Follow-Up Studies; Humans; Hysterectomy; Lymph Node Excision; Male; Middle Aged; Neoplasm Grading; Postoperative Complications; Prognosis; Radiotherapy; Adjuvant; Survival Rate; Uterine Cervical Neoplasms; Young AdultSurvival RateOncologyChemotherapy AdjuvantCarcinoma Squamous CellFemaleFluorouracilAdultmedicine.medical_specialtyGynecologic oncologyHysterectomyYoung AdultmedicineHumansChemotherapyRadical HysterectomyRadical surgeryconcomitant chemoradiationSurvival rateAgedHysterectomyRadiotherapybusiness.industryCarcinomamedicine.diseaseSurgerySettore MED/40 - GINECOLOGIA E OSTETRICIASquamous CellConcomitantLymph Node ExcisionRadiotherapy AdjuvantSurgeryLymphadenectomyCisplatinNeoplasm GradingbusinessFollow-Up StudiesAnnals of Surgical Oncology
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Robotic Radical Hysterectomy After Concomitant Chemoradiation in Locally Advanced Cervical Cancer: A Prospective Phase II Study

2016

Study Objective To assess the feasibility of total robotic radical surgery (TRRS) in patients with locally advanced cervical cancer (LACC) who receive chemoradiation therapy (CT/RT). Design A prospective (preplanned) study of a nonrandomized controlled trial (Canadian Task Force classification level 2). Setting Catholic University of the Sacred Hearth, Rome, Italy. Patients Between September 2013 and January 2016, a total of 40 patients with LACC (Fédération Internationale de Gynécologie et d'Obstétrique stage IB2–III) were enrolled in the study. Interventions Robotic radical hysterectomy (RRH) plus pelvic and/or aortic lymphadenectomy was attempted within 6 weeks after CT/RT. The feasibili…

Adultmedicine.medical_specialtyLocally advancedPhases of clinical researchUterine Cervical NeoplasmsChemoradiation; Locally advanced cervical cancer; Robotic radical hysterectomyHysterectomy03 medical and health sciences0302 clinical medicinePostoperative ComplicationsRobotic Surgical ProceduresRobotic radical hysterectomymedicineHumansIn patientRadical surgeryRadical HysterectomyChemoradiation; Locally advanced cervical cancer; Robotic radical hysterectomy; Obstetrics and GynecologyAgedCervical cancerLocally advanced cervical cancer030219 obstetrics & reproductive medicinebusiness.industryObstetrics and GynecologyChemoradiotherapy AdjuvantMiddle Agedmedicine.diseaseCombined Modality TherapySurgerySettore MED/40 - GINECOLOGIA E OSTETRICIAChemoradiation030220 oncology & carcinogenesisConcomitantCarcinoma Squamous CellDisease ProgressionFeasibility StudiesLymph Node ExcisionFemaleLaparoscopybusiness
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Perioperative morbidity and rate of upstaging after laparoscopic staging for patients with locally advanced cervical cancer: results of a prospective…

2015

Objective The International Federation of Gynecology and Obstetrics (FIGO) staging for cervical cancer is based on clinical examination. Previous studies have demonstrated significant upstaging with surgical staging. However, no randomized trial has ever shown a survival benefit when radiation combined with chemoradiation (RCTX) is modified according to surgical staging. The objective of the study was to evaluate the feasibility and outcomes of surgical staging prior to radical RCTX treatment among patients with locally advanced cervical cancer in the setting of a larger, prospective, randomized study (the Uterus-11 study of the German Gynecologic Oncology Group). Study Design Between 2009 …

Uterine Cervical Neoplasmmedicine.medical_treatmentBrachytherapyUterine Cervical NeoplasmsCarcinoma AdenosquamouAntineoplastic AgentPostoperative ComplicationsLaparotomyrandomized triallocally advanced cervical cancerLaparoscopyCervical cancermedicine.diagnostic_testMedicine (all)Lymph NodeObstetrics and GynecologyChemoradiotherapyMiddle Agedlaparoscopic stagingTreatment OutcomeCarcinoma Squamous CellFemaleoperative morbidityHumanAdultmedicine.medical_specialtyPelviBrachytherapyAntineoplastic AgentsGynecologic oncologyAdenocarcinomaPelvisCarcinoma AdenosquamousYoung AdultmedicineHumansExternal beam radiotherapyAgedNeoplasm StagingRadiotherapybusiness.industryPostoperative complicationPerioperativemedicine.diseaseSurgeryFeasibility StudieFeasibility StudiesLymph Node ExcisionLaparoscopyPostoperative ComplicationLymph NodesCisplatinbusinessAmerican journal of obstetrics and gynecology
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Minimally Invasive Approaches in Locally Advanced Cervical Cancer Patients Undergoing Radical Surgery After Chemoradiotherapy: A Propensity Score Ana…

2020

Abstract Purpose Chemoradiation (CT/RT) followed by radical surgery (RS) may play a role in locally advanced cervical cancer (LACC) patients with suboptimal response to CT/RT or in low-income countries with limited access to radiotherapy. Our aim is to evaluate oncological and surgical outcomes of minimally invasive radical surgery (MI-RS) compared with open radical surgery (O-RS). Patients and Methods Data for stage IB2–IVA cervical cancer patients managed by CT/RT and RS were retrospectively analyzed. Results Beginning with 686 patients, propensity score matching resulted in 462 cases (231 per group), balanced for FIGO stage, lymph node status, histotype, tumor grade, and clinical respons…

medicine.medical_specialtymedicine.medical_treatmentConcomitant Chemoradiation Neoadjuvant Chemotherapy Phase III Hysterectomy Radiation Therapy WomenUterine Cervical NeoplasmsHysterectomyDisease-Free Survival03 medical and health sciences0302 clinical medicinePhase IIIlocally advanced cervical cancer (LACC)locally advanced cervical cancerHumansMedicineWomenChemoradiotherapy; Disease-Free Survival; Female; Humans; Hysterectomy; Neoadjuvant Therapy; Neoplasm Recurrence Local; Neoplasm Staging; Propensity Score; Retrospective Studies; Uterine Cervical Neoplasms030212 general & internal medicineStage (cooking)Radical surgeryPropensity ScoreNeoadjuvant therapyNeoplasm StagingRetrospective StudiesCervical cancerHysterectomyRadiationbusiness.industrylocally advanced cervical cancer surgeryNeoadjuvant ChemotherapyRetrospective cohort studyChemoradiotherapyGynecologic Oncologymedicine.diseaseNeoadjuvant TherapySurgeryRadiation therapySettore MED/40 - GINECOLOGIA E OSTETRICIANeoplasm RecurrenceLocalOncology030220 oncology & carcinogenesisConcomitant ChemoradiationFemaleSurgeryTherapyNeoplasm Recurrence LocalbusinessChemoradiotherapy
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Validation of tumour-free distance as novel prognostic marker in early-stage cervical cancer: a retrospective, single-centre, cohort study

2021

Background: The aim of the present study was to assess the prognostic value of tumour-free distance (TFD), defined as the minimum distance of uninvolved stroma between the tumour and peri-cervical stromal ring, in early-stage cervical cancer. Methods: Patients with pathologic FIGO 2009 stage IA1–IIA2 cervical cancer, treated by primary radical surgical treatment between 01/2000 and 11/2019, were retrospectively included. Adjuvant treatment was administered according to the presence of previously established pathologic risk factors. TFD was measured histologically on the hysterectomy specimen. Pre-operative TFD measured at MRI-scan from a cohort of patients was reviewed and compared with pat…

AdultOncologyCancer Researchmedicine.medical_specialtyMultivariate analysismedicine.medical_treatmentUterine Cervical NeoplasmsHysterectomyArticlesurgery03 medical and health sciences0302 clinical medicineSurgical oncologyInternal medicinelocally advanced cervical cancerHumansMedicineStage (cooking)AgedNeoplasm StagingRetrospective StudiesAged 80 and overCervical cancer...Hysterectomybusiness.industrylocally advanced cervical cancer surgeryMiddle AgedPrognosismedicine.diseaseMagnetic Resonance ImagingSurvival AnalysisSettore MED/40 - GINECOLOGIA E OSTETRICIATreatment OutcomeOncologyLymphatic Metastasis Magnetic Resonance ImagingLymphatic Metastasis030220 oncology & carcinogenesisCohortRadiographic Image Interpretation Computer-AssistedFemaleLymphbusinessCohort studyBritish Journal of Cancer
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